Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes

被引:144
作者
Pacher, P
Szabó, C
机构
[1] NIAAA, NIH, Lab Physiol Studies, Rockville, MD 20852 USA
[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Newark, NJ 07103 USA
关键词
D O I
10.1016/j.coph.2006.01.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hyperglycemic episodes, which complicate even well-controlled cases of diabetes, lead to increased polyol pathway flux, activation of protein kinase C and accelerated nonenzymatic formation of advanced glycation end products. Many of these pathways become activated in response to the production of superoxide anion. Superoxide can interact with nitric oxide, forming the potent cytotoxin peroxynitrite. Peroxynitrite attacks various biomolecules in the vascular endothelium, vascular smooth muscle and myocardium, eventually leading to cardiovascular dysfunction via multiple mechanisms. This review focuses on emerging evidence suggesting that peroxynitrite plays a key role in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic retinopathy, neuropathy and nephropathy.
引用
收藏
页码:136 / 141
页数:6
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