Analysis and assessment of comparative modeling predictions in CASP4

被引：110

作者：

Tramontano, A

Leplae, R

Morea, V

机构：

[1] Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy

[2] Sanger Ctr, Cambridge, England

[3] MRC, Mol Biol Lab, Div Struct Studies, Cambridge CB2 2QH, England

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2001年

关键词：

Critical Assessment of Methods of Protein; Structure Prediction (CASP); comparative modeling; evaluation of protein models;

D O I：

10.1002/prot.10015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe here the results of our analysis of the comparative modeling predictions submitted to the fourth round of Critical Assessment of Structure Prediction (CASP4). On the basis of a numerical evaluation of the models, we assessed their ability to predict the overall fold correctly, the relative orientation of domains in multidomain proteins, the conformation of the side chains, the loop regions, and the biologically important residues of the targets. We also discuss the performance of automatic prediction servers and compare the results of CASP4 with those obtained in CASP3. (C) 2002 Wiley-Liss, Inc.

引用

页码：22 / 38

页数：17

共 15 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].