Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

被引：642

作者：

Brennan, Patrick J. ^{[1
]}

Brigl, Manfred ^{[2
]}

Brenner, Michael B. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CD1D-RESTRICTED NKT CELLS; ANTIGEN-PRESENTING CELLS; ROR-GAMMA-T; ALPHA-GALACTOSYLCERAMIDE; CUTTING EDGE; IN-VIVO; DENDRITIC CELLS; B-CELLS; AIRWAY HYPERREACTIVITY; IMMUNE-RESPONSE;

D O I：

10.1038/nri3369

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Invariant natural killer T (iNKT) cells exist in a 'poised effector' state, which enables them to rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor, they recognize self and foreign lipid antigens presented by CD1d in a conserved manner, but their activation can catalyse a spectrum of polarized immune responses. In this Review, we discuss recent advances in our understanding of the innate-like mechanisms underlying iNKT cell activation and describe how lipid antigens, the inflammatory milieu and interactions with other immune cell subsets regulate the functions of iNKT cells in health and disease.

引用

页码：101 / 117

页数：17

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