Rejuvenating views of the ageing process

被引:23
作者
Helfand, SL
Inouye, SK
机构
[1] Univ Connecticut, Ctr Hlth, Sch Med, Farmington, CT 06030 USA
[2] Yale Univ, Sch Med, New Haven, CT 06504 USA
关键词
D O I
10.1038/nrg726
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Commonly held assumptions about the ageing process have guided and directed research in this important area over many years. Recent evidence, however, from disciplines as diverse as molecular genetics, clinical epidemiology and demography, provide a direct challenge to the validity of many of these assumptions. So, the time is ripe to re-examine these assumptions about the ageing process and to rethink the scientific foundations of the field.
引用
收藏
页码:149 / 153
页数:5
相关论文
共 66 条
[1]   THE EVOLVING CONCEPT OF THE HEALTHY WORKER SURVIVOR EFFECT [J].
ARRIGHI, HM ;
HERTZPICCIOTTO, I .
EPIDEMIOLOGY, 1994, 5 (02) :189-196
[2]  
Bartke A, 2000, RES PRO CEL, V29, P181
[3]   Dwarf mice and the ageing process [J].
BrownBorg, HM ;
Borg, KE ;
Meliska, CJ ;
Bartke, A .
NATURE, 1996, 384 (6604) :33-33
[4]   Age determination and validation studies of marine fishes: do deep-dwellers live longer? [J].
Cailliet, GM ;
Andrews, AH ;
Burton, EJ ;
Watters, DL ;
Kline, DE ;
Ferry-Graham, LA .
EXPERIMENTAL GERONTOLOGY, 2001, 36 (4-6) :739-764
[5]  
CAREY JR, 1992, SCIENCE, V258, P457, DOI 10.1126/science.1411540
[6]   Mortality dynamics of density in the Mediterranean fruit fly [J].
Carey, JR ;
Liedo, P ;
Vaupel, JW .
EXPERIMENTAL GERONTOLOGY, 1995, 30 (06) :605-629
[7]   Ageing: Levelling of the grim reaper [J].
Charlesworth, B ;
Partridge, L .
CURRENT BIOLOGY, 1997, 7 (07) :R440-R442
[8]  
CHATTERJEE B, 1981, J BIOL CHEM, V256, P5939
[9]   Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein [J].
Clancy, DJ ;
Gems, D ;
Harshman, LG ;
Oldham, S ;
Stocker, H ;
Hafen, E ;
Leevers, SJ ;
Partridge, L .
SCIENCE, 2001, 292 (5514) :104-106
[10]   Assessment of growth parameters and life span of GHR/BP gene-disrupted mice [J].
Coschigano, KT ;
Clemmons, D ;
Bellush, LL ;
Kopchick, JJ .
ENDOCRINOLOGY, 2000, 141 (07) :2608-2613