Liver transplantation as a therapeutic option for hepatocellular carcinoma

被引:4
作者
Matsunami, H
Shimizu, Y
Lynch, SV
Balderson, GA
Ando, Y
Strong, RW
机构
[1] Matsunami Gen Hosp, Dept Surg, Gifu 5016062, Japan
[2] Princess Alexandra Hosp, Queensland Liver Transplant Serv, Brisbane, Qld 4102, Australia
关键词
liver transplantation; hepatocellular carcinoma; living donor; lamivudine; ribavirin;
D O I
10.1159/000048281
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Better outcomes of the patients receiving liver transplantation for viral hepatitis and hepatocellular carcinoma (HCC) are achieved by improved patient selection and perioperative treatment with antiviral agents including lamivudine, ribavirin and interferon. Patient selection is accomplished by high-quality imaging as well as exclusion of patients with large tumors, obvious extrahepatic disease or macroscopic vascular invasion. Using such criteria, a 5-year survival of 92% has been reached in the Queensland Liver Transplant Service on a small number of highly selected patients with HCC. The treatment algorithm of Makuuchi has guided us in recommending resection, estimating to what extent the liver resection can be performed safely, and timing liver transplantation when it is the only option. Adult-to-adult living-donor liver transplantation is being performed safely in many centers worldwide. The transplantation of liver from living donors to HCC patients, when standard criteria for the likelihood of good outcomes are fulfilled, will increase in Japan in the near future. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码:82 / 86
页数:5
相关论文
共 16 条
  • [1] Pilot study of the combination of interferon alfa and ribavirin as therapy of recurrent hepatitis C after liver transplantation
    Bizollon, T
    Palazzo, U
    Ducerf, C
    Chevallier, M
    Elliott, M
    Baulieux, J
    Pouyet, M
    Trepo, C
    [J]. HEPATOLOGY, 1997, 26 (02) : 500 - 504
  • [2] CARR BI, 1993, TRANSPLANT P, V25, P1128
  • [3] A PRELIMINARY TRIAL OF LAMIVUDINE FOR CHRONIC HEPATITIS-B INFECTION
    DIENSTAG, JL
    PERRILLO, RP
    SCHIFF, ER
    BARTHOLOMEW, M
    VICARY, C
    RUBIN, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (25) : 1657 - 1661
  • [4] Resection or transplantation for hepatocellular carcinoma in cirrhotic patients: Outcomes based on indicated treatment strategy
    Figueras, J
    Jaurrieta, E
    Valls, C
    Ramos, E
    Serrano, T
    Rafecas, A
    Fabregat, J
    Torras, J
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2000, 190 (05) : 580 - 587
  • [5] Preoperative hepatic artery chemoembolization followed by orthotopic liver transplantation for hepatocellular carcinoma
    Harnois, DM
    Steers, J
    Andrews, JC
    Rubin, JC
    Pitot, HC
    Burgart, L
    Wiesner, RH
    Gores, GJ
    [J]. LIVER TRANSPLANTATION AND SURGERY, 1999, 5 (03): : 192 - 199
  • [6] IWATSUKI S, 1985, ANN SURG, V202, P401, DOI 10.1097/00000658-198510000-00001
  • [7] HEPATIC RESECTION VERSUS TRANSPLANTATION FOR HEPATOCELLULAR-CARCINOMA
    IWATSUKI, S
    STARZL, TE
    SHEAHAN, DG
    YOKOYAMA, I
    DEMETRIS, AJ
    TODO, S
    TZAKIS, AG
    VANTHIEL, DH
    CARR, B
    SELBY, R
    MADARIAGA, J
    [J]. ANNALS OF SURGERY, 1991, 214 (03) : 221 - 229
  • [8] Living related liver transplantation in adults
    Kawasaki, S
    Makuuchi, M
    Matsunami, H
    Hashikura, Y
    Ikegami, T
    Nakazawa, Y
    Chisuwa, H
    Terada, M
    Miyagawa, S
    [J]. ANNALS OF SURGERY, 1998, 227 (02) : 269 - 274
  • [9] Liver transplantation for hepatocellular carcinoma - A registry report of the impact of tumor characteristics on outcome
    Klintmalm, GB
    [J]. ANNALS OF SURGERY, 1998, 228 (04) : 479 - 488
  • [10] The prediction of risk of recurrence and time to recurrence of hepatocellular carcinoma after orthotopic liver transplantation: A pilot study
    Marsh, JW
    Dvorchik, I
    Subotin, M
    Balan, V
    Rakela, J
    Popechitelev, EP
    Subbotin, V
    Casavilla, A
    Carr, BI
    Fung, JJ
    Iwatsuki, S
    [J]. HEPATOLOGY, 1997, 26 (02) : 444 - 450