Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy

被引：249

作者：

Sarasin-Filipowicz, Magdalena ^{[1
,2
]}

Krol, Jacek ^{[3
]}

Markiewicz, Ilona ^{[3
]}

Heim, Markus H. ^{[1
,2
]}

Filipowicz, Witold ^{[3
]}

机构：

[1] Univ Basel, Dept Biomed, CH-4031 Basel, Switzerland

[2] Univ Basel Hosp, Div Gastroenterol & Hepatol, CH-4031 Basel, Switzerland

[3] Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

来源：

NATURE MEDICINE | 2009年 / 15卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

PLUS RIBAVIRIN; VIRUS-INFECTION; EXPRESSION; MODULATION;

D O I：

10.1038/nm.1902

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several microRNAs (miRNAs), including liver-specific miR-122, have been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Our analysis of liver biopsies from subjects with chronic hepatitis C (CHC) undergoing IFN therapy revealed no correlation of miR-122 expression with viral load and markedly decreased pretreatment miR-122 levels in subjects who had no virological response during later IFN therapy; other investigated miRNAs showed only limited changes. These data have implications for the prospect of targeting miRNAs for CHC therapy.

引用

页码：31 / 33

页数：3

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