The double-edged sword of Nrf2: Subversion of redox homeostasis during the evolution of cancer

被引：107

作者：

Hayes, JD ^{[1
]}

McMahon, M ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Biomed Res Ctr, Dundee DD1 9SY, Scotland

来源：

MOLECULAR CELL | 2006年 / 21卷 / 06期

关键词：

D O I：

10.1016/j.molcel.2006.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Low levels of Nrf2 activity predispose cells to chemical carcinogenesis. Surprisingly, Padmanabhan et al. (2006) provide evidence in a recent issue of Molecular Cell to support the notion that elevated Nrf2 activity may also play a role in the evolution of cancer.

引用

页码：732 / 734

页数：3

共 8 条

[1] Nrf2 is essential for protection against acute pulmonary injury in mice [J].

Chan, KM ;

Kan, YW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12731-12736

[2] Role of NRF2 in protection against hyperoxic lung injury in mice [J].

Cho, HY ;

Jedlicka, AE ;

Reddy, SP ;

Kensler, TW ;

Yamamoto, M ;

Zhang, LY ;

Kleeberger, SR .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2002, 26 (02) :175-182

[3] CLONAL ADAPTATION DURING CARCINOGENESIS [J].

FARBER, E .

BIOCHEMICAL PHARMACOLOGY, 1990, 39 (12) :1837-1846

[4] The C. elegans p38 MAPK rathway regulates nuclear ocalization of the transcription factor SKN-1 in oxidative stress response [J].

Inoue, H ;

Hisamoto, N ;

An, JH ;

Oliveira, RP ;

Nishida, E ;

Blackwell, TK ;

Matsumoto, K .

GENES & DEVELOPMENT, 2005, 19 (19) :2278-2283

[5] Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity [J].

Okawa, H ;

Motohashi, H ;

Kobayashi, A ;

Aburatani, H ;

Kensler, TW ;

Yamamoto, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 339 (01) :79-88

[6] Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer [J].

Padmanabhan, B ;

Tong, KI ;

Ohta, T ;

Nakamura, Y ;

Scharlock, M ;

Ohtsuji, M ;

Kang, MI ;

Kobayashi, A ;

Yokoyama, S ;

Yamamoto, M .

MOLECULAR CELL, 2006, 21 (05) :689-700

[7] Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice [J].

Ramos-Gomez, M ;

Kwak, MK ;

Dolan, PM ;

Itoh, K ;

Yamamoto, M ;

Talalay, P ;

Kensler, TW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) :3410-3415

[8] Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice [J].

Rangasamy, T ;

Cho, CY ;

Thimmulappa, RK ;

Zhen, LJ ;

Srisuma, SS ;

Kensler, TW ;

Yamamoto, M ;

Petrache, I ;

Tuder, RM ;

Biswal, S .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (09) :1248-1259

← 1 →