In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone

被引：5

作者：

Aizawa, M

Ito, M

Itatani, K

Suemasu, H

Nozue, A

Okada, I

Matsumoto, M

Ishikawa, M

Matsumoto, H

Toyama, Y

机构：

[1] Sophia Univ, Fac Sci & Technol, Dept Chem, Chiyoda Ku, Tokyo 1028554, Japan

[2] Sophia Univ, Fac Sci & Technol, Dept Mech Engn, Chiyoda Ku, Tokyo 1028554, Japan

[3] Keio Univ, Sch Med, Dept Orthopaed Surg, Shinjuku Ku, Tokyo 1608582, Japan

来源：

BIOCERAMICS 14 | 2002年 / 218-2卷

关键词：

hydroxyapatite; PMMA; ceramics/polymer hybrid material; biocompatibility; tissue reaction; osteoblast; mechanical property;

D O I：

10.4028/www.scientific.net/KEM.218-220.465

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.

引用

页码：465 / 468

页数：4

共 6 条

[1] Fabrication of porous ceramics with well-controlled open pores by sintering of fibrous hydroxyapatite particles [J].