Serum antibodies against circulating influenza strains among vaccinated and unvaccinated general practitioners during two consecutive years (2002-2003)

被引：13

作者：

Michiels, B ^{[1
]}

Philips, H ^{[1
]}

Coenen, S ^{[1
]}

Denekens, J ^{[1
]}

Van Royen, P ^{[1
]}

机构：

[1] Univ Antwerp, Ctr Gen Pract, B-2610 Antwerp, Belgium

来源：

VACCINE | 2006年 / 24卷 / 16期

关键词：

influenza vaccines; general practitioner; antibodies;

D O I：

10.1016/j.vaccine.2006.01.040

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Efficacy studies have not answered the question whether influenza vaccination among general practitioners (GPs) has a substantial additive effect on their immunity. To evaluate this effect the influenza antibody titres in vaccinated and unvaccinated GPs were compared in a controlled trial during two consecutive winter periods (2002-2003 and 2003-2004). The seroprotection rates against the circulating A/H3N2 influenza virus amount to 80% and 42% in the unvaccinated group in 2002 and 2003, respectively. In the vaccinated GPs the seroprotection rate increases from 91% to 96% in 2002 and from 70% to 83% in 2003 after vaccination. Besides vaccination, the (high) basic antibody titre before vaccination and working in a child and family preventive medicine unit were predicting a protective antibody level in GPs. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3145 / 3152

页数：8

共 25 条

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