Increased phospholipid fatty acid remodeling in human and rat prostatic adenocarcinoma tissues

被引:43
作者
Faas, FH
Dang, AQ
Pollard, M
Hong, XM
Fan, K
Luckert, PH
Schutz, M
机构
[1] UNIV ARKANSAS MED SCI HOSP,JOHN L MCCLELLAN MEM VET HOSP,DEPT MED,LITTLE ROCK,AR 72205
[2] UNIV ARKANSAS MED SCI HOSP,JOHN L MCCLELLAN MEM VET HOSP,DEPT UROL,LITTLE ROCK,AR 72205
[3] UNIV ARKANSAS MED SCI HOSP,JOHN L MCCLELLAN MEM VET HOSP,DEPT PATHOL,LITTLE ROCK,AR 72205
[4] UNIV NOTRE DAME,LOBUND LAB,NOTRE DAME,IN 46556
关键词
prostatic neoplasms; arachidonic acid; prostaglandins; acyltransferases; fatty acid desaturases;
D O I
10.1016/S0022-5347(01)66009-9
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: To study the mechanism of diminished arachidonic acid levels in malignant prostatic tissues. Materials and Methods: Benign and malignant prostate tissues were obtained from human radical prostatectomy specimens and from rats using Pollard's Lobund/Wistar rat prostate cancer model. Fatty acid composition and a variety of enzyme activities involved in maintaining phospholipid fatty acid composition were compared in malignant and benign prostatic tissues. Results: Decreased arachidonic acid levels, previously reported in human prostate cancer, were present in malignant rat as well as in human tissues. There were 21% and 26% decreases of arachidonic acid levels in the rat and human malignant tissues compared with benign tissues. Fatty acid desaturase activity was undetectable. Fatty acyl-CoA hydrolase and synthetase activities were not altered in the malignant tissues. However, there was a 2-fold increase in phospholipase A(2) activity and a 4- to 12-fold increase in fatty acyl-CoA lysophosphatidylcholine acyltransferase activity in malignant rat and human prostatic tissues. Conclusions: These data indicate that, in malignant prostate tissues, the fatty acid remodeling mechanism is activated through the deacylation-reacylation cycle. This process may be a result of increased use of arachidonic acid for the formation of prostaglandins that may be crucial for the further development and growth of the malignant tissues.
引用
收藏
页码:243 / 248
页数:6
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