Versatile synthesis of (+)-deoxypyridinoline, a biochemical marker for diagnosis of osteoporosis

被引：18

作者：

Adamczyk, M ^{[1
]}

Akireddy, SR ^{[1
]}

Reddy, RE ^{[1
]}

机构：

[1] Abbott Labs, Div Diagnost, Div Organ Chem Res, Abbott Pk, IL 60064 USA

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 16期

关键词：

D O I：

10.1016/S0957-4166(99)00329-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A versatile chiral synthesis of the bone collagen cross-link, (+)-deoxypyridinoline (Dpd, 1) was described starting from a 3-hydroxypyridine derivative (2) via sequential introduction of three amino acid chains followed by hydrolysis. The key synthon 2, was prepared from vitamin B-6 (6). (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：3107 / 3110

页数：4

共 36 条

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