Neurological perspectives on voltage-gated sodium channels

被引：266

作者：

Eijkelkamp, Niels ^{[1
]}

Linley, John E. ^{[1
]}

Baker, Mark D. ^{[2
]}

Minett, Michael S. ^{[1
]}

Cregg, Roman ^{[1
]}

Werdehausen, Robert ^{[1
,3
]}

Rugiero, Francois ^{[1
]}

Wood, John N. ^{[1
]}

机构：

[1] UCL, Wolfson Inst Biomed Res, Mol Nocicept Grp, London WC1E 6BT, England

[2] Neurosci Inst Cell & Mol Sci Barts & London Sch M, London E1 2AT, England

[3] Univ Dusseldorf, Fac Med, Dept Anaesthesiol, D-40225 Dusseldorf, Germany

来源：

BRAIN | 2012年 / 135卷

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

ion channel; genetics; pain; epilepsy; SCN1A; EXTREME PAIN DISORDER; SEVERE MYOCLONIC EPILEPSY; SPINAL SENSORY NEURONS; PERSISTENT NA+ CURRENT; FEBRILE SEIZURES-PLUS; GATING CHARGE MOVEMENT; ROOT GANGLION NEURONS; OF-FUNCTION MUTATIONS; TETRODOTOXIN-RESISTANT; NEUROPATHIC PAIN;

D O I：

10.1093/brain/aws225

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors.

引用

页码：2585 / 2612

页数：28

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