An improved synthesis of resveratrol

被引：44

作者：

Farina, A ^{[1
]}

Ferranti, C ^{[1
]}

Marra, C ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

来源：

NATURAL PRODUCT RESEARCH | 2006年 / 20卷 / 03期

关键词：

resveratrol; Heck reaction; Wittig reaction; stilbene; protective group;

D O I：

10.1080/14786410500059532

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this article we report an improved total synthesis of resveratrol, increasing the overall yield from 22 to 71%. The synthesis reported in our previous publication was made up of two fundamental steps: a Wittig reaction and a Heck coupling. Here we studied these steps separately to increase the individual yields. The yield of the Wittig reaction was increased up to 98%; however, we could not find better reaction conditions for the Heck coupling than those reported in the previous article.

引用

页码：247 / 252

页数：6

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