The role of thrombospondin-1 in tumor progression and angiogenesis

被引:104
作者
Tuszynski, GP
Nicosia, RF
机构
[1] MED COLL PENN,DEPT MED,PHILADELPHIA,PA 19129
[2] MED COLL PENN,DEPT PATHOL,PHILADELPHIA,PA 19129
[3] HAHNEMANN UNIV,PHILADELPHIA,PA 19129
关键词
D O I
10.1002/bies.950180113
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Thrombospondin (TSP-I) is a large glycoprotein secreted by platelets and synthesized by many cell types, including endothelial and tumor cells. Although controversy exists about the biological function of TSP-1, the following observations suggest that TSP-1 may potentiate tumor progression. (1) Tumor metastases in mice are promoted by TSP-1 and inhibited by anti-TSP-l antibodies. (2) TSP-I promotes tumor cell adhesion, migration and invasion. (3) TSP-1 promotes angiogenesis in the rat aorta model. (4) TSP-I up-regulates the plasminogen activator system through a mechanism involving the activation of TGF-beta 1. (5) Human tumors express increased levels of the CSVTCG-specific TSP-1 receptor. (6) Tumor stroma is enriched in TSP-1. (7) Cancer patients have high blood levels of TSP-1. (8) Poor patient survival correlates with a higher expression of the CSVTCG-specific TSP-1 receptor on tumor cells. In this paper we discuss the evidence that TSP-1 promotes tumor progression and present a hypothetical scheme for its mechanism of action.
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页码:71 / 76
页数:6
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