Necrotizing enterocolitis: Pathophysiology, platelet-activating factor, and probiotics

被引：41

作者：

Frost, Brandy L. ^{[1
]}

Caplan, Michael S. ^{[1
]}

机构：

[1] Univ Chicago, Dept Pediat, NorthShore Univ HealthSyst, Pritzker Sch Med, Evanston, IL USA

来源：

SEMINARS IN PEDIATRIC SURGERY | 2013年 / 22卷 / 02期

关键词：

Necrotizing enterocolitis; Platelet-activating factor; Probiotics; Prematurity; ISCHEMIC BOWEL NECROSIS; WEIGHT PRETERM INFANTS; MUCIN GENE-EXPRESSION; FACTOR-ACETYLHYDROLASE; DOUBLE-BLIND; BIFIDOBACTERIUM SEPTICEMIA; INTESTINAL FLORA; RAT MODEL; PREVENTION; SUPPLEMENTATION;

D O I：

10.1053/j.sempedsurg.2013.01.005

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Although smaller and younger preterm neonates can now survive long term due to advances in neonatal medicine, necrotizing enterocolitis (NEC) continues to plague the clinicians caring for these tiny patients. Research studies have contributed to our understanding of this complex disease, including the role of platelet-activating factor (PAF), but preventative and treatment strategies remain limited. One promising preventative measure in recent years has been enteral supplementation of probiotics, but concerns remain regarding the optimal use of these organisms, and safe administration must be assured. This chapter reviews NEC pathophysiology, including the role of PAP, as well as literature on the use of probiotics in the preterm infant. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：88 / 93

页数：6

共 61 条

[1]

Decreased expression of toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide [J].

Abreu, MT ;

Vora, P ;

Faure, E ;

Thomas, LS ;

Arnold, ET ;

Arditi, M .

JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1609-1616

[2]

AlFaleh K, 2011, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD005496.pub3, 10.1097/AOG.0b013e3181726f2f]

[3]

ALLEN A, 1982, ADV EXP MED BIOL, V144, P115

[4]

Platelet-activating factor concentration in the stool of human newborns: Effects of enteral feeding and neonatal necrotizing enterocolitis [J].

Amer, MD ;

Hedlund, E ;

Rochester, J ;

Caplan, MS .

BIOLOGY OF THE NEONATE, 2004, 85 (03) :159-166

[5]

MACROMOLECULAR ABSORPTION IN PRETERM AND TERM INFANTS [J].

AXELSSON, I ;

JAKOBSSON, I ;

LINDBERG, T ;

POLBERGER, S ;

BENEDIKTSSON, B ;

RAIHA, N .

ACTA PAEDIATRICA SCANDINAVICA, 1989, 78 (04) :532-537

[6]

GESTATIONAL EVOLUTION OF SMALL-INTESTINE MOTILITY IN PRETERM AND TERM INFANTS [J].

BERSETH, CL .

JOURNAL OF PEDIATRICS, 1989, 115 (04) :646-651

[7]

Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial [J].

Besselink, Marc G. H. ;

van Santvoort, Hjalmar C. ;

Buskens, Erik ;

Boermeester, Marja A. ;

van Goor, Harry ;

Timmerman, Harro M. ;

Nieuwenhuijs, Vincent B. ;

Bollen, Thomas L. ;

van Ramshorst, Bert ;

Witteman, Ben J. M. ;

Rosman, Camiel ;

Ploeg, Rutger J. ;

Brink, Menno A. ;

Schaapherder, Alexander F. M. ;

Dejong, Cornelis H. C. ;

Wahab, Peter J. ;

van Laarhoven, Cees J. H. M. ;

van der Harst, Erwin ;

van Eijck, Casper H. J. ;

Cuesta, Miguel A. ;

Akkermans, Louis M. A. ;

Gooszen, Hein G. .

LANCET, 2008, 371 (9613) :651-659

[8]

Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates [J].

Bin-Nun, A ;

Bromiker, R ;

Wilschanski, M ;

Kaplan, M ;

Rudensky, B ;

Caplan, M ;

Hammerman, C .

JOURNAL OF PEDIATRICS, 2005, 147 (02) :192-196

[9]

Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial [J].

Braga, Taciana Duque ;

Pontes da Silva, Giselia Alves ;

Cabral de Lira, Pedro Israel ;

Lima, Marilia de Carvalho .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2011, 93 (01) :81-86

[10]

Mucin gene expression in human embryonic and fetal intestine [J].

Buisine, MP ;

Devisme, L ;

Savidge, TC ;

Gespach, C ;

Gosselin, B ;

Porchet, N ;

Aubert, JP .

GUT, 1998, 43 (04) :519-524

← 1 2 3 4 5 6 7 →