Scopoletin:: An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei

被引：57

作者：

Kang, TH

Pae, HO

Jeong, SJ

Yoo, JC

Choi, BM

Jun, CD

Chung, HT

Miyamoto, T

Higuchi, R

Kim, YC ^{[1
]}

机构：

[1] Wonkwang Univ, Coll Pharm, Iksan 570749, Chonbuk, South Korea

[2] Wonkwang Univ, Sch Med, Iksan 570749, Chonbuk, South Korea

[3] Wonkwang Univ, Med Resources Res Ctr, Iksan 570749, Chonbuk, South Korea

[4] Kyushu Univ, Fac Pharmaceut Sci, Fukuoka 812, Japan

来源：

PLANTA MEDICA | 1999年 / 65卷 / 05期

关键词：

Artemisia feddei; Compositae; scopoletin; nitric oxide; inducible nitric oxide synthesis;

D O I：

10.1055/s-1999-14014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of an H2O extract of Artemisia feddei has furnished an inducible nitric oxide synthase (iNOS) inhibitory coumarin, scopoletin (1) and one of the inactive sesquiterpenes, achillin (2). Compound 1 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was due to suppression of iNOS mRNA and iNOS protein, as determined by Northern and Western blotting, respectively.

引用

页码：400 / 403

页数：4

共 14 条

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