GABAB receptor:: a site of therapeutic benefit

被引：178

作者：

Bowery, NG ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Verona Biol, Psychiat Ctr Excellence Drug Discovery, I-37135 Verona, Italy

来源：

CURRENT OPINION IN PHARMACOLOGY | 2006年 / 6卷 / 01期

关键词：

D O I：

10.1016/j.coph.2005.10.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Although the presence of functional GABA(B) receptors in mammalian brain has been known for more than 20 years, there is still only one therapeutic agent in use, baclofen, which mediates its effects directly via this receptor. However, activation of this receptor can produce numerous effects that might be amenable to drug development. Evidence from preclinical studies also suggests that antagonism of the GABAB receptor produces beneficial clinical effects.

引用

页码：37 / 43

页数：7

共 48 条

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