Neurobiology of nitrous oxide-induced antinociceptive effects

被引:78
作者
Fujinaga, M [1 ]
Maze, M
机构
[1] Chelsea & Westminster Hosp, Magill Dept Anaesthesia Intens Care & Pain Manage, London, England
[2] Univ London Imperial Coll Sci Technol & Med, Dept Anaesthesia & Intens Care, London, England
基金
英国医学研究理事会;
关键词
nitrous oxide; analgesia; antinociceptive effect; descending inhibitory pathway; opioid peptides; adrenoceptor; GABA;
D O I
10.1385/MN:25:2:167
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Nitrous oxide (N2O), or laughing gas, has been used for clinical anesthesia for more than a century and is still commonly used. While the anesthetic/hypnotic mechanisms of N2O remain largely unknown, the underlying mechanisms of its analgesic/antinociceptive effects have been elucidated during the last several decades. Evidence to date indicate that N2O induces opioid peptide release in the periaqueductal gray area of the midbrain leading to the activation of the descending inhibitory pathways, which results in modulation of the pain/nociceptive processing in the spinal cord. The types of opioid peptide induced by N2O and the subtypes of opioid receptors that mediate the antinociceptive effects of N2O appear to depend on various factors including the species and/or strain, the regions of the brain, and the paradigms of behavior testing used for the experiments. Among three types of descending inhibitory pathways, the descending noradrenergic inhibitory pathway seems to play the most prominent role. The specific elements involved are now being resolved.
引用
收藏
页码:167 / 189
页数:23
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