Physiological and metabolic implications of V-ATPase isoforms in the kidney

被引：18

作者：

Karet, FE

机构：

[1] Univ Cambridge, Cambridge Inst Med Res, Div Renal Med, Addenbrookes Hosp, Cambridge CB2 2XY, England

[2] Univ Cambridge, Cambridge Inst Med Res, Dept Med Genet, Addenbrookes Hosp, Cambridge CB2 2XY, England

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2005年 / 37卷 / 06期

基金：

英国惠康基金;

关键词：

kidney; V-ATPase; renal tubular acidosis;

D O I：

10.1007/s10863-005-9484-x

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Not all vacuolar-type H+-ATPases (V-ATPases) are alike; those responsible for H+ movement across plasma membranes contain some different, tissue-specific subunit isoforms. This brief review outlines those that have special relevance to the kidney, and illustrates their importance by describing various human diseases where loss of local proton pump function not only confers a severe phenotype, but has revealed related tissues where these same isoforms are expressed, signifying their physiological importance.

引用

收藏

页码：425 / 429

页数：5

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