Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway

被引：344

作者：

Ji, Qing ^{[1
,2
,3
]}

Liu, Xuan ^{[1
]}

Fu, Xiaoling ^{[1
]}

Zhang, Long ^{[2
,3
]}

Sui, Hua ^{[1
]}

Zhou, Lihong ^{[1
]}

Sun, Jian ^{[2
,3
]}

Cai, Jianfeng ^{[4
]}

Qin, Jianmin ^{[2
,3
]}

Ren, Jianlin ^{[5
]}

Li, Qi ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Dept Med Oncol, Shuguang Hosp, Shanghai, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Intervent Canc Inst, Shanghai, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Dept Gen Surg, Shanghai, Peoples R China

[4] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[5] Shanghai Municipal Hosp Tradit Chinese Med, Dept Oncol, Shanghai, Peoples R China

来源：

PLOS ONE | 2013年 / 8卷 / 11期

基金：

中国国家自然科学基金;

关键词：

POLYGONUM-CUSPIDATUM; NONCODING RNA; DOWN-REGULATION; EXPRESSION; EXTRACT; GROWTH; ANTIOXIDANT; TARGET;

D O I：

10.1371/journal.pone.0078700

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Resveratrol, extracted from Chinese herbal medicine Polygonum cuspidatum, is known to inhibit invasion and metastasis of human colorectal cancer (CRC), in which long non-coding Metastasis Associated Lung Adenocarcinoma Transcript 1 (RNA-MALAT1) also plays an important role. Using MALAT1 lentiviral shRNA and over-expression constructs in CRC derived cell lines, LoVo and HCT116, we demonstrated that the anti-tumor effects of resveratrol on CRC are through inhibiting Wnt/beta-catenin signaling, thus the expression of its target genes such as c-Myc, MMP-7, as well as the expression of MALAT1. In detail, resveratrol down-regulates MALAT1, resulting in decreased nuclear localization of beta-catenin thus attenuated Wnt/beta-catenin signaling, which leads to the inhibition of CRC invasion and metastasis. This finding of ours surely provides important pre-clinical evidence supporting future use of resveratrol in prevention and treatment of CRC.

引用

页数：12

共 36 条

[1]

Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications [J].