Autism - Family connections

被引:8
作者
Geschwind, Daniel H. [1 ,2 ]
机构
[1] Univ Calif Los Angeles, Program Neurogenet, Dept Neurol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst, Los Angeles, CA 90095 USA
关键词
D O I
10.1038/454838a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Autism is a common neurodevelopmental syndrome with a strong genetic component. The study of autistic individuals whose parents are cousins highlights the genetic diversity of this condition.
引用
收藏
页码:838 / 839
页数:2
相关论文
共 12 条
  • [1] Advances in autism genetics: on the threshold of a new neurobiology
    Abrahams, Brett S.
    Geschwind, Daniel H.
    [J]. NATURE REVIEWS GENETICS, 2008, 9 (05) : 341 - 355
  • [2] Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene
    Alarcon, Maricela
    Abrahams, Brett S.
    Stone, Jennifer L.
    Duvall, Jacqueline A.
    Perederiy, Julia V.
    Bomar, Jamee M.
    Sebat, Jonathan
    Wigler, Michael
    Martin, Christa L.
    Ledbetter, David H.
    Nelson, Stanley E.
    Cantor, Rita M.
    Geschwind, Daniel H.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (01) : 150 - 159
  • [3] Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system
    Flavell, Steven W.
    Greenberg, Michael E.
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 2008, 31 : 563 - 590
  • [4] Autism spectrum disorders: developmental disconnection syndromes
    Geschwind, Daniel H.
    Levitt, Pat
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2007, 17 (01) : 103 - 111
  • [5] Array-based comparative genomic hybridisation identifies high frequency of cryptic chromosomal rearrangements in patients with syndromic autism spectrum disorders
    Jacquemont, M-L
    Sanlaville, D.
    Redon, R.
    Raoul, O.
    Cormier-Daire, V.
    Lyonnet, S.
    Amiel, J.
    Le Merrer, M.
    Heron, D.
    de Blois, M-C
    Prieur, M.
    Vekemans, M.
    Carter, N. P.
    Munnich, A.
    Colleaux, L.
    Philippe, A.
    [J]. JOURNAL OF MEDICAL GENETICS, 2006, 43 (11) : 843 - 849
  • [6] Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
    Jamain, S
    Quach, H
    Betancur, C
    Råstam, M
    Colineaux, C
    Gillberg, IC
    Soderstrom, H
    Giros, B
    Leboyer, M
    Gillberg, C
    Bourgeron, T
    Gillberg, C
    Råstam, M
    Gillberg, C
    Nydén, A
    Söderström, H
    Leboyer, M
    Betancur, C
    Philippe, A
    Giros, B
    Colineaux, C
    Cohen, D
    Chabane, N
    Mouren-Siméoni, MC
    Brice, A
    Sponheim, E
    Spurkland, I
    Skjeldal, OH
    Coleman, M
    Pearl, PL
    Cohen, IL
    Tsiouris, J
    Zappella, M
    Menchetti, G
    Pompella, A
    Aschauer, H
    Van Maldergem, L
    [J]. NATURE GENETICS, 2003, 34 (01) : 27 - 29
  • [7] HOMOZYGOSITY MAPPING - A WAY TO MAP HUMAN RECESSIVE TRAITS WITH THE DNA OF INBRED CHILDREN
    LANDER, ES
    BOTSTEIN, D
    [J]. SCIENCE, 1987, 236 (4808) : 1567 - 1570
  • [8] Structural variation of chromosomes in autism spectrum disorder
    Marshall, Christian R.
    Noor, Abdul
    Vincent, John B.
    Lionel, Anath C.
    Feuk, Lars
    Skaug, Jennifer
    Shago, Mary
    Moessner, Rainald
    Pinto, Dalila
    Ren, Yan
    Thiruvahindrapduram, Bhoorna
    Fiebig, Andreas
    Schreiber, Stefan
    Friedman, Jan
    Ketelaars, Cees E. J.
    Vos, Yvonne J.
    Ficicioglu, Can
    Kirkpatrick, Susan
    Nicolson, Rob
    Sloman, Leon
    Surnmers, Anne
    Gibbons, Clare A.
    Teebi, Ahmad
    Chitayat, David
    Weksberg, Rosanna
    Thompson, Ann
    Vardy, Cathy
    Crosbie, Vicki
    Luscombe, Sandra
    Baatjes, Rebecca
    Zwaigenbaum, Lonnie
    Roberts, Wendy
    Fernandez, Bridget
    Szatmari, Peter
    Scherer, Stephen W.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (02) : 477 - 488
  • [9] Identifying autism loci and genes by tracing recent shared ancestry
    Morrow, Eric M.
    Yoo, Seung-Yun
    Flavell, Steven W.
    Kim, Tae-Kyung
    Lin, Yingxi
    Hill, Robert Sean
    Mukaddes, Nahit M.
    Balkhy, Soher
    Gascon, Generoso
    Hashmi, Asif
    Al-Saad, Samira
    Ware, Janice
    Joseph, Robert M.
    Greenblatt, Rachel
    Gleason, Danielle
    Ertelt, Julia A.
    Apse, Kira A.
    Bodell, Adria
    Partlow, Jennifer N.
    Barry, Brenda
    Yao, Hui
    Markianos, Kyriacos
    Ferland, Russell J.
    Greenberg, Michael E.
    Walsh, Christopher A.
    [J]. SCIENCE, 2008, 321 (5886) : 218 - 223
  • [10] Lessons from studying monogenic disease for common disease
    Peltonen, L
    Perola, M
    Naukkarinen, J
    Palotie, A
    [J]. HUMAN MOLECULAR GENETICS, 2006, 15 : R67 - R74