Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

被引：384

作者：

Cooper, Jason D. ^{[1
]}

Smyth, Deborah J. ^{[1
]}

Smiles, Adam M. ^{[2
]}

Plagnol, Vincent ^{[1
]}

Walker, Neil M. ^{[1
]}

Allen, James E. ^{[1
]}

Downes, Kate ^{[1
]}

Barrett, Jeffrey C. ^{[1
]}

Healy, Barry C. ^{[1
]}

Mychaleckyj, Josyf C. ^{[3
]}

Warram, James H. ^{[2
]}

Todd, John A. ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Juvenile Diabet Res Fdn,Cambridge Inst Med Res, Wellcome Trust Diabet & Inflammat Lab,Dept Med Ge, Cambridge CB2 0XY, England

[2] Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

[3] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 12期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1038/ng.249

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 x 10(-8)) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)).

引用

页码：1399 / 1401

页数：3

共 15 条

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