Isolation and characterization of a sigB deletion mutant of Staphylococcus aureus

被引：79

作者：

Nicholas, RO ^{[1
]}

Li, T ^{[1
]}

McDevitt, D ^{[1
]}

Marra, A ^{[1
]}

Sucoloski, S ^{[1
]}

Demarsh, PL ^{[1
]}

Gentry, DR ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Antiinfect Res, Collegeville, PA 19426 USA

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 07期

关键词：

D O I：

10.1128/IAI.67.7.3667-3669.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The sigB gene of Staphylococcus aureus, coding for the alternate sigma factor B, has been deleted by allelic replacement mutagenesis. The mutant grew as well as the parent in vitro, although it was deficient in clumping factor, coagulase, and pigment. In two murine and one rat infection model the mutant showed no reduction in virulence.

引用

页码：3667 / 3669

页数：3

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