UK Biobank: Current status and what it means for epidemiology

被引：363

作者：

Allen, Naomi ^{[1
,2
,3
]}

Sudlow, Cathie ^{[1
,4
]}

Downey, Paul ^{[1
]}

Peakman, Tim ^{[1
]}

Danesh, John ^{[5
]}

Elliott, Paul ^{[6
]}

Gallacher, John ^{[7
]}

Green, Jane ^{[8
]}

Matthews, Paul ^{[9
]}

Pell, Jill ^{[10
]}

Sprosen, Tim ^{[11
]}

Collins, Rory ^{[1
,2
,3
]}

机构：

[1] UK Biobank, Stockport, Lancs, England

[2] Univ Oxford, Clin Trial Serv Unit, Oxford OX3 7LF, England

[3] Univ Oxford, Epidemiol Studies Unit, Oxford OX3 7LF, England

[4] Univ Edinburgh, Div Clin Neurosci, Edinburgh, Midlothian, Scotland

[5] Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England

[6] Univ London Imperial Coll Sci Technol & Med, MRC HPA Ctr Environm & Hlth, London SW7 2AZ, England

[7] Neuadd Meirionnydd, Dept Primary Care & Publ Hlth, Cardiff, S Glam, Wales

[8] Univ Oxford, Canc Epidemiol Unit, Oxford OX3 7LF, England

[9] Univ London Imperial Coll Sci Technol & Med, Div Brain Sci, Dept Med, London SW7 2AZ, England

[10] Univ Glasgow, Inst Hlth & Wellbeing, Glasgow G12 8QQ, Lanark, Scotland

[11] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London SW7 2AZ, England

来源：

HEALTH POLICY AND TECHNOLOGY | 2012年 / 1卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/j.hlpt.2012.07.003

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

UK Biobank is a very large prospective study which aims to provide a resource for the investigation of the genetic, environmental and lifestyle determinants of a wide range of diseases of middle age and later life. Between 2006 and 2010, over 500,000 men and women aged 40 to 69 years were recruited and extensive data on participants' lifestyles, environment, medical history and physical measures, along with biological samples, were collected. The health of the participants is now being followed long-term, principally through linkage to a wide range of health-related records, with validation and characterisation of health-related outcomes. Further enhancements are also underway to improve phenotype characterisation, including internet-based dietary assessment, biomarker measurements on the baseline blood samples and, in sub-samples of the cohort, physical activity monitoring and proposals for extensive brain and body imaging. UK Biobank is now available for use by all researchers, without exclusive or preferential access, for any health-related research that is in the public interest. The open-access nature of the resource will allow researchers from around the world to conduct research that leads to better strategies for the prevention, diagnosis and treatment of a wide range of life-threatening and disabling conditions. (C) 2012 Fellowship of Postgraduate Medicine. Published by Elsevier Ltd. All rights reserved.

引用

页码：123 / 126

页数：4

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