Management of non-small-cell lung cancer: recent developments

被引：883

作者：

Reck, Martin ^{[1
]}

Heigener, David F. ^{[1
]}

Mok, Tony ^{[3
]}

Soria, Jean-Charles ^{[4
,5
]}

Rabe, Klaus F. ^{[1
,2
]}

机构：

[1] Airway Res Ctr North, LungenClin Grosshansdorf, D-22927 Grosshansdorf, Germany

[2] Univ Kiel, Dept Med, Airway Res Ctr North, Kiel, Germany

[3] Chinese Univ Hong Kong, Dept Clin Oncol, Hong Kong Canc Inst, State Key Lab South China, Hong Kong, Hong Kong, Peoples R China

[4] Inst Gustave Roussy Villejuif, Dept Med, Paris, France

[5] Univ South Paris, Paris, France

来源：

LANCET | 2013年 / 382卷 / 9893期

关键词：

FINE-NEEDLE-ASPIRATION; PHASE-III TRIAL; POSTOPERATIVE ADJUVANT CHEMOTHERAPY; CISPLATIN PLUS GEMCITABINE; ENDOSCOPIC ULTRASOUND; 1ST-LINE TREATMENT; DOUBLE-BLIND; MAINTENANCE THERAPY; RADIATION-THERAPY; SUPPORTIVE CARE;

D O I：

10.1016/S0140-6736(13)61502-0

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Non-small-cell lung cancer is one of the leading causes of deaths from cancer worldwide. Therefore, improvements in diagnostics and treatments are urgently needed. In this review, we will discuss the evolution of lung cancer staging towards more non-invasive, endoscopy-based, and image-based methods, and the development of stage-adapted treatment. A special focus will be placed on the role of novel surgical approaches and modern radiotherapy strategies for early stages of disease, the effect of multimodal treatment in locally advanced disease, and ongoing developments in the treatment of patients with metastatic disease. In particular, we will include an emphasis on targeted therapies, which are based on the assumption that a treatable driver mutation or gene rearrangement is present within the tumour. Finally, the position of lung cancer treatment on the pathway to personalised therapy will be discussed.

引用

页码：709 / 719

页数：11

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