Laboratory-developed simulated moving bed for chiral drug separations - Design of the system and separation of tramadol enantiomers

被引：57

作者：

Cavoy, E ^{[1
]}

Deltent, MF ^{[1
]}

Lehoucq, S ^{[1
]}

Miggiano, D ^{[1
]}

机构：

[1] UNIV MONS,B-7000 MONS,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 769卷 / 01期

关键词：

enantiomer separation; preparative chromatography; simulated moving bed; tramadol;

D O I：

10.1016/S0021-9673(96)00964-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The design of a laboratory-developed simulated moving bed (SMB) is described. The main features of the system are outlined. The efficiency of the SMB to resolve chiral drugs is illustrated by the separation of Tramadol enantiomers at various feed concentrations. Advantages over preparative batch chromatography in terms of solvent and chiral phase consumption are demonstrated.

引用

页码：49 / 57

页数：9

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