Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes.: Part I.: Silymarin and its flavonolignans

被引：67

作者：

Chlopcíková, A ^{[1
]}

Psotová, J ^{[1
]}

Miketová, P ^{[1
]}

Simánek, V ^{[1
]}

机构：

[1] Inst Med Chem & Biochem, Fac Med, Olomouc 77515, Czech Republic

来源：

PHYTOTHERAPY RESEARCH | 2004年 / 18卷 / 02期

关键词：

silymarin; flavonolignans; rat cardiomyocyte; doxorubicin; chemoprotective activity; ATP;

D O I：

10.1002/ptr.1415

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Silymarin, an extract of flavonolignans from the dried fruits of milk thistle (Silybum marianum L. Gaertneri) and its constituents silibinin, dehydrosilibinin, silychristin and silydianin were tested for protective effects on rat cardiomyocytes exposed to doxorubicin. Silymarin and individual flavonolignans did not exert cytotoxicity in the range 25-100 mum (incubation 9 h). Dehydrosilibinin was tested only at 25 mum concentration due to its low solubility. All substances increased the cell ATP level. Silymarin and flavonolignans displayed a dose-dependent cytoprotection against doxorubicin (100 mum, incubation 8 h). The protective effects of silymarin, silibinin, dehydrosilibinin and silychristin were comparable to that of dexrasoxane, while silydianin exerted the, best protective effect. The ability of silymarin complex and its components to protect cardiomyocytes against doxorubicin-induced oxidative stress is due mainly to their cell membrane stabilization effect, radical scavenging and iron chelating potency. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：107 / 110

页数：4

共 23 条

[1] Silybin, a new iron-chelating agent [J].

Borsari, M ;

Gabbi, C ;

Ghelfi, F ;

Grandi, R ;

Saladini, M ;

Severi, S ;

Borella, F .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2001, 85 (2-3) :123-129

[2]

CHLOPCIKOVA S, 2003, IN PRESS PHYTOTHER R

[3]

Chlopcikova Sarka, 2001, Biomedical Papers (Olomouc), V145, P49

[4]

Dorr RT, 1996, SEMIN ONCOL, V23, P23

[5]

Dvorák Z, 2003, TOXICOL LETT, V137, P201, DOI 10.1016/S0378-4274(02)00406-X

[6] Milk thistle (Silybum marianum) for the therapy of liver disease [J].

Flora, K ;

Hahn, M ;

Rosen, H ;

Benner, K .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 1998, 93 (02) :139-143

[7] Doxorubicin-induced apoptosis: Implications in cardiotoxicity [J].

Kalyanaraman, B ;

Joseph, J ;

Kalivendi, S ;

Wang, SW ;

Konorev, E ;

Kotamraju, S .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2002, 234 (01) :119-124

[8] DOXORUBICIN (ADRIAMYCIN) - A CRITICAL-REVIEW OF FREE RADICAL-DEPENDENT MECHANISMS OF CYTOTOXICITY [J].

KEIZER, HG ;

PINEDO, HM ;

SCHUURHUIS, GJ ;

JOENJE, H .

PHARMACOLOGY & THERAPEUTICS, 1990, 47 (02) :219-231

[9]

KUNTZ E, 1998, SILYMARIN TREATMENT, P7

[10]

LENTZEN H, 1998, Patent No. 5714473

← 1 2 3 →