Role of sarco/endoplasmic reticulum calcium content and calcium ATPase activity in the control of cell growth and proliferation

被引：81

作者：

Lipskaia, Larissa ^{[1
]}

Hulot, Jean-Sebastien ^{[1
]}

Lompre, Anne-Marie ^{[1
]}

机构：

[1] Univ Paris 06, INSERM, UMR S 621, Fac Med Pitie Salpetriere, F-75013 Paris, France

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2009年 / 457卷 / 03期

关键词：

Sarcoplasmic reticulum calcium transporting ATPases; Cell growth processes; Calcium signaling; ACTIVATED T-CELLS; SMOOTH-MUSCLE-CELLS; CAPACITATIVE CA2+ ENTRY; INTERACTION MOLECULE-1 STIM1; PULMONARY-ARTERY MYOCYTES; RECEPTOR TYROSINE KINASE; STAGE HEART-FAILURE; SARCOPLASMIC-RETICULUM; NUCLEAR FACTOR; ENDOPLASMIC-RETICULUM;

D O I：

10.1007/s00424-007-0428-7

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Ca2+, the main second messenger, is central to the regulation of cellular growth. There is increasing evidence that cellular growth and proliferation are supported by a continuous store-operated Ca2+ influx. By controlling store refilling, the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) also controls store-operated calcium entry and, thus, cell growth. In this review, we discuss data showing the involvement of SERCA in the regulation of proliferation and hypertrophy. First, we describe the Ca2+-related signaling pathways involved in cell growth. Then, we present evidence that SERCA controls proliferation of differentiated cells and hypertrophic growth of cardiomyocytes, and discuss the role of SERCA isoforms. Last, we consider the potential therapeutic applications of increasing SERCA activity for the treatment of cardiovascular diseases and of modulating SERCA and SR content for the treatment of cancer.

引用

页码：673 / 685

页数：13

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