The synthesis of lysine alpha-ketoamide thrombin inhibitors via an epoxy amide ring opening.

被引：7

作者：

Cacciola, J

Alexander, RS

Fevig, JM

Stouten, PFW

机构：

[1] Dept. of Chem. and Physical Sciences, DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0500

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(97)01205-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a novel route for the preparation of substituted alpha-ketoamides of lysine. These compounds, due to the presence of an electrophilic carbonyl, display submicromolar activity toward the enzyme thrombin. (C) 1997 The DuPont Merck Pharmaceutical Company.

引用

收藏

页码：5741 / 5744

页数：4

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