Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis

被引：14

作者：

Cao, Chao ^{[1
,2
]}

Chen, Zhong-Bo ^{[1
]}

Sun, Shi-Fang ^{[1
]}

Yu, Yi-Ming ^{[1
]}

Ding, Qun-Li ^{[1
]}

Deng, Zai-Chun ^{[1
]}

机构：

[1] Ningbo Univ, Affiliated Hosp, Sch Med, Dept Resp Med, Ningbo 315020, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Resp & Crit Care Med, Hangzhou 310009, Zhejiang, Peoples R China

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

关键词：

CARCINOEMBRYONIC ANTIGEN CEA; CYFRA; 21-1; EXPRESSION; SERUM; BENIGN; NSE; BRONCHOSCOPY; ASSOCIATION; UTILITY; SCC;

D O I：

10.1038/srep03473

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF form the malignant group was significantly higher compared with that of the benign groups (P = 0.018). However, no statistical difference was observed in BALF CEA (P = 0.375) or CYFRA21-1 (P = 0.838) between lung cancer patients and nonmalignant controls. With a cut-off value of 2.06 ng/ml, NSE had a sensitivity of 72.9%, a specificity of 69.2%, respectively, in predicting the malignant nature of pulmonary mass. Our study observed that the level of VEGF-C was increased in BALF of patients with squamous cell carcinoma. Moreover, we found that NSE was significantly higher in BALF of lung cancer patients than in benign diseases.

引用

页数：4

共 29 条

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