Asymmetric Diels-Alder reactions of α,β-unsaturated aldehydes catalyzed by a diarylprolinol silyl ether salt in the presence of water

被引：134

作者：

Hayashi, Yujiro ^{[1
]}

Samanta, Sampak ^{[1
]}

Gotoh, Hiroaki ^{[1
]}

Ishikawa, Hayato ^{[1
]}

机构：

[1] Tokyo Univ Sci, Dept Ind Chem, Fac Engn, Shinjuku Ku, Tokyo 1628601, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 35期

关键词：

asymmetric synthesis; cycloaddition; enantioselectivity; organocatalysis; water chemistry;

D O I：

10.1002/anie.200801408

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Water, water, everywhere: The title reaction predominantly affords the exo isomer with excellent enantioselectivity (see scheme; TMS=trimethylsilyl). The synthesis can be carried out without organic solvents and provides the products by distillation. Water increases the rate and enantioselectivity of the reaction. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6634 / 6637

页数：4

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