Recent insights into the role of NF-κB in ovarian carcinogenesis

被引：27

作者：

Alvero, Ayesha B. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06510 USA

来源：

GENOME MEDICINE | 2010年 / 2卷

关键词：

Epithelial Ovarian Cancer; Epithelial Ovarian Cancer Cell; Epithelial Ovarian Cancer Patient; Enhance Cell Growth; CAOV3 Cell;

D O I：

10.1186/gm177

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

The NF-kappa Bs are a family of ubiquitously expressed transcription factors that have been described to be responsible for the establishment of an inflammatory response. Studies in the past decade have also demonstrated this family's role in the initiation and progression of hematological and solid tumors. Recently, research has uncovered a specific role for NF-kappa Bs in the development and maintenance of ovarian cancer.

引用

页数：3

共 21 条

[1]

Stem-Like Ovarian Cancer Cells Can Serve as Tumor Vascular Progenitors [J].

Alvero, Ayesha B. ;

Fu, Han-Hsuan ;

Holmberg, Jennie ;

Visintin, Irene ;

Mor, Liora ;

Marquina, Carlos Cano ;

Oidtman, Jessica ;

Silasi, Dan-Arin ;

Mor, Gil .

STEM CELLS, 2009, 27 (10) :2405-2413

[2]

Molecular phenotyping of human ovarian cancer stem cells unravel the mechanisms for repair and chemo-resistance [J].

Alvero, Ayesha B. ;

Chen, Rui ;

Fu, Han-Hsuan ;

Montagna, Michele ;

Schwartz, Peter E. ;

Rutherford, Thomas ;

Silasi, Dan-Arin ;

Steffensen, Karina D. ;

Waldstrom, Marianne ;

Visintin, Irene ;

Mor, Gil .

CELL CYCLE, 2009, 8 (01) :158-166

[3]

Nuclear Factor κB Transcription Factors Are Coexpressed and Convey a Poor Outcome in Ovarian Cancer [J].

Annunziata, Christina M. ;

Stavnes, Helene Tuft ;

Kleinberg, Lilach ;

Berner, Aasmund ;

Hernandez, Lidia F. ;

Birrer, Michael J. ;

Steinberg, Seth M. ;

Davidson, Ben ;

Kohn, Elise C. .

CANCER, 2010, 116 (13) :3276-3284

[4]

Regulation of IKKβ by miR-199a affects NF-κB activity in ovarian cancer cells [J].

Chen, R. ;

Alvero, A. B. ;

Silasi, D. A. ;

Kelly, M. G. ;

Fest, S. ;

Visintin, I. ;

Leiser, A. ;

Schwartz, P. E. ;

Rutherford, T. ;

Mor, G. .

ONCOGENE, 2008, 27 (34) :4712-4723

[5]

Systematic review of first-line chemotherapy for newly diagnosed postoperative patients with stage II, III, or IV epithelial ovarian cancer [J].

Covens, A ;

Carey, M ;

Bryson, P ;

Verma, S ;

Fung, MFK ;

Johnston, M .

GYNECOLOGIC ONCOLOGY, 2002, 85 (01) :71-80

[6]

CRAMER DW, 1983, JNCI-J NATL CANCER I, V71, P717

[7]

TWEAK promotes ovarian cancer cell metastasis via NF-κB pathway activation and VEGF expression [J].

Dai, Lan ;

Gu, Liying ;

Ding, Chuanwei ;

Qiu, Lihua ;

Di, Wen .

CANCER LETTERS, 2009, 283 (02) :159-167

[8]

Expression of classical NF-κB pathway effectors in human ovarian carcinoma [J].

Darb-Esfahani, Silvia ;

Sinn, Bruno V. ;

Weichert, Wilko ;

Budczies, Jan ;

Lehmann, Annika ;

Noske, Aurelia ;

Buckendahl, Ann-Christin ;

Mueller, Berit Maria ;

Sehouli, Jalid ;

Koensgen, Dominique ;

Gyoerffy, Balazs ;

Dietel, Manfred ;

Denkert, Carsten .

HISTOPATHOLOGY, 2010, 56 (06) :727-739

[9]

MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-κB1 [J].

Guo, Li-Min ;

Pu, Yong ;

Han, Zhe ;

Liu, Tao ;

Li, Yi-Xuan ;

Liu, Min ;

Li, Xin ;

Tang, Hua .

FEBS JOURNAL, 2009, 276 (19) :5537-5546

[10]

Increased staining for phosphorylated AKT and nuclear factor-κB p65 and their relationship with prognosis in epithelial ovarian cancer [J].

Guo, Rui-Xia ;

Qiao, Yu-Huan ;

Zhou, Yan ;

Li, Liu-Xia ;

Shi, Hui-Rong ;

Chen, Kui-Sheng .

PATHOLOGY INTERNATIONAL, 2008, 58 (12) :749-756

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