Spinal cord atrophy in multiple sclerosis caused by white matter volume loss

被引：43

作者：

Gilmore, CP

DeLuca, GC

Bo, L

Owens, T

Lowe, J

Esiri, MM

Evangelou, N

机构：

[1] Univ Nottingham, Queens Med Ctr, Dept Neurol, NHS Trust, Nottingham NG7 2UH, England

[2] Univ Nottingham, Dept Econ, Nottingham NG7 2UH, England

[3] Univ Nottingham, Dept Neuropathol, Nottingham NG7 2UH, England

[4] Univ Oxford, Dept Clin Neurol, Oxford, England

[5] Oxford Radcliffe Natl Hlth Serv, Dept Neuropathol, Oxford, England

[6] Vrije Univ Amsterdam, Dept Neuropathol, NL-1081 HV Amsterdam, Netherlands

[7] Haukeland Univ Hosp, Natl Competence Ctr Multiple Sclerosis, Dept Neurol, N-5021 Bergen, Norway

来源：

ARCHIVES OF NEUROLOGY | 2005年 / 62卷 / 12期

关键词：

D O I：

10.1001/archneur.62.12.1859

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To assess the relative contributions of white matter (WM) and gray matter (GM) volume loss to spinal cord atrophy in multiple sclerosis (MS). Design: Postmortem study of transverse sections obtained from 5 levels of the spinal cord, with measurement of the cross-sectional GM and WM areas. Setting: Department of Neuropathology, University of Nottingham, Nottingham, England. Patients: Fifty-five MS cases and 33 controls. Main Outcome Measures: Size of the WM and GM areas. Results: The WM area was significantly reduced in MS cases in the upper but not the lower cord levels. The GM area was not significantly different between MS and control cases. Conclusion: Spinal cord atrophy in MS is due to WM rather than GM volume loss.

引用

页码：1859 / 1862

页数：4

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