Sprouting of A beta fibers into lamina II of the rat dorsal horn in peripheral neuropathy

被引：103

作者：

Lekan, HA

Carlton, SM

Coggeshall, RE

机构：

[1] UNIV TEXAS,MED BRANCH,INST MARINE BIOMED,GALVESTON,TX 77555

[2] UNIV TEXAS,MED BRANCH,DEPT ANAT & NEUROSCI,GALVESTON,TX 77555

来源：

NEUROSCIENCE LETTERS | 1996年 / 208卷 / 03期

关键词：

plasticity; primary afferents; spinal cord; nociception;

D O I：

10.1016/0304-3940(96)12566-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cholera toxin beta-subunit conjugated to horseradish peroxidase was used to label the large myelinated (A beta) fiber input to the dorsal horn in a model of peripheral neuropathy induced by tight ligation of the L5 and L6 spinal nerves. Following induction of neuropathy, A beta fibers were present in lamina II of the ipsilateral dorsal horn, a region normally devoid of A beta input. This reorganization of large fiber input to the superficial dorsal horn provides some anatomical basis for sensory changes found in this model of neuropathic pain.

引用

页码：147 / 150

页数：4

共 31 条

[1]

CHOI Y, 1994, PAIN, V59, P369, DOI 10.1016/0304-3959(94)90023-X

[2] ABNORMALITIES OF SYMPATHETIC INNERVATION IN THE AREA OF AN INJURED PERIPHERAL-NERVE IN A RAT MODEL OF NEUROPATHIC PAIN [J].