The antitumoral compound Kahalalide F acts on cell lysosomes

被引：77

作者：

GarciaRocha, M

Bonay, P

Avila, J

机构：

[1] Centro de Biología Molecular, Univ. Autónoma de Madrid

来源：

CANCER LETTERS | 1996年 / 99卷 / 01期

关键词：

Kahalalide F; cytoskeleton; lysosomes; Golgi apparatus; endoplasmic reticulum;

D O I：

10.1016/0304-3835(95)04036-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The target for the antitumoral peptidic drug, Kahalalide F, has been studied in cultured cells. In the presence of the compound, the cells became impressively swollen, showing the formation of large vacuoles. The formation of these vacuoles appears to be the consequence of changes in lysosomal membranes. Thus, lysosomes are a target for Kahalalide F action.

引用

页码：43 / 50

页数：8

共 15 条

[1] BAI R, 1991, J BIOL CHEM, V266, P15882
[2] DOLASTATIN-10, A POWERFUL CYTOSTATIC PEPTIDE DERIVED FROM A MARINE ANIMAL - INHIBITION OF TUBULIN POLYMERIZATION MEDIATED THROUGH THE VINCA ALKALOID BINDING DOMAIN
BAI, R
PETTIT, GR
HAMEL, E
[J]. BIOCHEMICAL PHARMACOLOGY, 1990, 39 (12) : 1941 - 1949
[3] THE CELL BIOLOGY OF MULTIPLE-DRUG RESISTANCE
BECK, WT
[J]. BIOCHEMICAL PHARMACOLOGY, 1987, 36 (18) : 2879 - 2887
[4] Brandes D, 1966, Int Rev Cytol, V20, P207, DOI 10.1016/S0074-7696(08)60802-5
[5] BRANDES D, 1963, ATL CANCER I MONOGR, V12, P29
[6] CHEMICAL PROSPECTORS SCOUR THE SEAS FOR PROMISING DRUGS
FLAM, F
[J]. SCIENCE, 1994, 266 (5189) : 1324 - 1325
[7] SV40-TRANSFORMED SIMIAN CELLS SUPPORT THE REPLICATION OF EARLY SV40 MUTANTS
GLUZMAN, Y
[J]. CELL, 1981, 23 (01) : 175 - 182
[8] GUNN S, 1956, J ENDOCRINOL, V16, P18
[9] CELL BIOLOGY - SNAPPY EXOCYTOXINS
HUTTNER, WB
[J]. NATURE, 1993, 365 (6442) : 104 - 105
[10] MOREMEN KW, 1991, J BIOL CHEM, V266, P16876

← 1 2 →