Two-step synthesis of the bipyrrole precursor of prodigiosins

被引:62
作者
Dairi, K [1 ]
Tripathy, S [1 ]
Attardo, G [1 ]
Lavallée, JF [1 ]
机构
[1] Gemin X Biotechnol Inc, Dept Med Chem, Montreal, PQ H2X 2H7, Canada
关键词
natural product; prodigiosins; tambjamines; haloformylation; bipyrrole; Suzuki coupling;
D O I
10.1016/j.tetlet.2006.02.035
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The key intermediate in the synthesis of prodigiosins, 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde, has been prepared in two steps and 65% overall yield from the commercially available 4-methoxy-3-pyrrolin-2-one. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2605 / 2606
页数:2
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