Association of angiotensin-converting enzyme gene polymorphism with lipid profiles in children and adolescents with insulin-dependent diabetes mellitus

被引：5

作者：

Kobayashi, K ^{[1
]}

Amemiya, S ^{[1
]}

Mochizuki, M ^{[1
]}

Kobayashi, K ^{[1
]}

Matsushita, K ^{[1
]}

Sawanobori, E ^{[1
]}

Ishihara, T ^{[1
]}

Higashida, K ^{[1
]}

Shimura, Y ^{[1
]}

Kato, K ^{[1
]}

Nakazawa, S ^{[1
]}

机构：

[1] Yamanashi Med Univ, Dept Pediat, Tamaho, Yamanashi 4093898, Japan

来源：

HORMONE RESEARCH | 1999年 / 51卷 / 04期

关键词：

angiotensin-converting enzyme gene polymorphism; atherosclerosis risk factors; insulin-dependent diabetes mellitus lipoprotein(a); adolescents;

D O I：

10.1159/000023358

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We attempted to clarify the association between angiotensin-converting enzyme (ACE) gene polymorphism and the other predictive factors for macroangiopathy in children and adolescents with uncomplicated insulin-dependent diabetes mellitus (IDDM), Sixty-three patients were divided into 3 groups according to the ACE genotypes. The lipid profiles were evaluated according to ACE genotypes, The level of lipoprotein(a) (Lp(a)) in the It genotype was significantly lower than that in groups with the D allele, Lp(a) significantly correlated with apo B/apo A-I (p < 0.001, r = 0.63) and atherogenic index (AI = (total cholesterol - high-density lipoprotein cholesterol)/high-density lipoprotein cholesterol; p = 0.004, r = 0.36), We suggest that the D allele may affect the level of Lp(a) and the other lipid profiles in IDDM.

引用

页码：201 / 204

页数：4

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