共 145 条
Epigenetic control of T-helper-cell differentiation
被引:536
作者:

Wilson, Christopher B.
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机构:
Univ Washington, Dept Immunol, Seattle, WA 98195 USA Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Rowell, Emily
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机构:
Univ Washington, Dept Immunol, Seattle, WA 98195 USA Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Sekimata, Masayuki
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机构:
Univ Washington, Dept Immunol, Seattle, WA 98195 USA Univ Washington, Dept Immunol, Seattle, WA 98195 USA
机构:
[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA
关键词:
GROWTH-FACTOR-BETA;
DISTAL REGULATORY ELEMENTS;
CYTOKINE GENE-EXPRESSION;
IFN-GAMMA PROMOTER;
DNA METHYLATION;
INTERFERON-GAMMA;
CUTTING EDGE;
TGF-BETA;
CHROMATIN MODIFICATIONS;
FUNCTIONAL PLASTICITY;
D O I:
10.1038/nri2487
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Naive CD4(+) T cells give rise to T-helper-cell subsets with functions that are tailored to their respective roles in host defence. The specification of T-helper-cell subsets is controlled by networks of lineage-specifying transcription factors, which bind to regulatory elements in genes that encode cytokines and other transcription factors. The nuclear context in which these transcription factors act is affected by epigenetic processes, which allow programmes of gene expression to be inherited by progeny cells that at the same time retain the potential for change in response to altered environmental signals. In this Review, we describe these epigenetic processes and discuss how they collaborate to govern the fate and function of T helper cells.
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页码:91 / 105
页数:15
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共 145 条
[1]
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
[J].
Acosta-Rodriguez, Eva V.
;
Rivino, Laura
;
Geginat, Jens
;
Jarrossay, David
;
Gattorno, Marco
;
Lanzavecchia, Antonio
;
Sallusto, Federica
;
Napolitani, Giorgio
.
NATURE IMMUNOLOGY,
2007, 8 (06)
:639-646

Acosta-Rodriguez, Eva V.
论文数: 0 引用数: 0
h-index: 0
机构: Inst Res Biomed, CH-6500 Bellinzona, Switzerland

Rivino, Laura
论文数: 0 引用数: 0
h-index: 0
机构: Inst Res Biomed, CH-6500 Bellinzona, Switzerland

Geginat, Jens
论文数: 0 引用数: 0
h-index: 0
机构: Inst Res Biomed, CH-6500 Bellinzona, Switzerland

Jarrossay, David
论文数: 0 引用数: 0
h-index: 0
机构: Inst Res Biomed, CH-6500 Bellinzona, Switzerland

Gattorno, Marco
论文数: 0 引用数: 0
h-index: 0
机构: Inst Res Biomed, CH-6500 Bellinzona, Switzerland

Lanzavecchia, Antonio
论文数: 0 引用数: 0
h-index: 0
机构: Inst Res Biomed, CH-6500 Bellinzona, Switzerland

Sallusto, Federica
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Res Biomed, CH-6500 Bellinzona, Switzerland Inst Res Biomed, CH-6500 Bellinzona, Switzerland

Napolitani, Giorgio
论文数: 0 引用数: 0
h-index: 0
机构: Inst Res Biomed, CH-6500 Bellinzona, Switzerland
[2]
Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 focus-activated precursors
[J].
Adeeku, Eric
;
Gudapati, Prathyusha
;
Mendez-Fernandez, Yanice
;
Van Kaer, Luc
;
Boothby, Mark
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2008, 105 (27)
:9307-9312

Adeeku, Eric
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Microbiol & Immunol, Nashville, TN 37232 USA Vanderbilt Univ, Dept Microbiol & Immunol, Nashville, TN 37232 USA

Gudapati, Prathyusha
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Microbiol & Immunol, Nashville, TN 37232 USA Vanderbilt Univ, Dept Microbiol & Immunol, Nashville, TN 37232 USA

Mendez-Fernandez, Yanice
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Microbiol & Immunol, Nashville, TN 37232 USA Vanderbilt Univ, Dept Microbiol & Immunol, Nashville, TN 37232 USA

论文数: 引用数:
h-index:
机构:

Boothby, Mark
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Microbiol & Immunol, Nashville, TN 37232 USA
Vanderbilt Univ, Dept Med, Nashville, TN 37232 USA Vanderbilt Univ, Dept Microbiol & Immunol, Nashville, TN 37232 USA
[3]
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
[J].
Agarwal, S
;
Rao, A
.
IMMUNITY,
1998, 9 (06)
:765-775

Agarwal, S
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA

Rao, A
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA
[4]
Long-range transcriptional regulation of cytokine gene expression
[J].
Agarwal, S
;
Rao, A
.
CURRENT OPINION IN IMMUNOLOGY,
1998, 10 (03)
:345-352

Agarwal, S
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA

Rao, A
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA
[5]
Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
[J].
Akimzhanov, Askar M.
;
Yang, Xuexian O.
;
Dong, Chen
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2007, 282 (09)
:5969-5972

Akimzhanov, Askar M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

Yang, Xuexian O.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

Dong, Chen
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
[6]
New nomenclature for chromatin-modifying enzymes
[J].
Allis, C. David
;
Berger, Shelley L.
;
Cote, Jacques
;
Dent, Sharon
;
Jenuwien, Thomas
;
Kouzarides, Tony
;
Pillus, Lorraine
;
Reinberg, Danny
;
Shi, Yang
;
Shiekhattar, Ramin
;
Shilatifard, Ali
;
Workman, Jerry
;
Zhang, Yi
.
CELL,
2007, 131 (04)
:633-636

Allis, C. David
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

Berger, Shelley L.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

Cote, Jacques
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

Dent, Sharon
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

论文数: 引用数:
h-index:
机构:

Kouzarides, Tony
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

Pillus, Lorraine
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

Reinberg, Danny
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

论文数: 引用数:
h-index:
机构:

Shiekhattar, Ramin
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

论文数: 引用数:
h-index:
机构:

Workman, Jerry
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

Zhang, Yi
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England
[7]
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
[J].
Amsen, D
;
Blander, JM
;
Lee, GR
;
Tanigaki, K
;
Honjo, T
;
Flavell, RA
.
CELL,
2004, 117 (04)
:515-526

Amsen, D
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

Blander, JM
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

Lee, GR
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

Tanigaki, K
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

Honjo, T
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

Flavell, RA
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA
[8]
Direct regulation of Gata3 expression determines the T helper differentiation potential of notch
[J].
Amsen, Derk
;
Antov, Andrey
;
Jankovic, Dragana
;
Sher, Alan
;
Radtke, Freddy
;
Souabni, Abdallah
;
Busslinger, Meinrad
;
McCright, Brent
;
Gridley, Thomas
;
Flavell, Richard A.
.
IMMUNITY,
2007, 27 (01)
:89-99

Amsen, Derk
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

Antov, Andrey
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

Jankovic, Dragana
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

Sher, Alan
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

Radtke, Freddy
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

Souabni, Abdallah
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

Busslinger, Meinrad
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

McCright, Brent
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

Gridley, Thomas
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

Flavell, Richard A.
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA
[9]
Post-transcriptional control of cytokine production
[J].
Anderson, Paul
.
NATURE IMMUNOLOGY,
2008, 9 (04)
:353-359

Anderson, Paul
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA
[10]
Phenotypic and functional features of human Th17 cells
[J].
Annunziato, Francesco
;
Cosmi, Lorenzo
;
Santarlasci, Veronica
;
Maggi, Laura
;
Liotta, Francesco
;
Mazzinghi, Benedetta
;
Parente, Eliana
;
Fili, Lucia
;
Ferri, Simona
;
Frosali, Francesca
;
Giudici, Francesco
;
Romagnani, Paola
;
Parronchi, Paola
;
Tonelli, Francesco
;
Maggi, Enrico
;
Romagnani, Sergio
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2007, 204 (08)
:1849-1861

Annunziato, Francesco
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Cosmi, Lorenzo
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Santarlasci, Veronica
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Maggi, Laura
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Liotta, Francesco
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Mazzinghi, Benedetta
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Parente, Eliana
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Fili, Lucia
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机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Ferri, Simona
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机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Frosali, Francesca
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机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Giudici, Francesco
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机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

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Parronchi, Paola
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机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Tonelli, Francesco
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h-index: 0
机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Maggi, Enrico
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h-index: 0
机构: Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy

Romagnani, Sergio
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机构:
Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy