Neuroendocrine differentiation and prognosis in prostatic adenocarcinoma

被引：70

作者：

McWilliam, LJ ^{[1
]}

Manson, C ^{[1
]}

George, NJR ^{[1
]}

机构：

[1] UNIV S MANCHESTER HOSP,NHS TRUST,WITHINGTON HOSP,DEPT UROL,MANCHESTER M20 2LR,LANCS,ENGLAND

来源：

BRITISH JOURNAL OF UROLOGY | 1997年 / 80卷 / 02期

关键词：

prostate; adenocarcinoma; neuroendocrine differentiation; prognosis;

D O I：

10.1046/j.1464-410X.1997.00300.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives To assess the prognostic importance of neuroendocrine differentiation in conventional (non-small cell) prostatic adenocarcinoma, Materials and methods Ninety-two samples from patients with prostatic adenocarcinoma were studied retrospectively. The immunohistochemical analysis of chromogranin A and neuron-specific enolase in formalin-fixed, paraffin wax embedded prostatic tissue chips was related to other prognostic variables and patient survival. Results Neuroendocrine differentiation was detected in 48 cases; there was a significant correlation with worsening tumour differentiation, the presence of bone metastases and with worsening survival, but no independent effect of neuroendocrine differentiation on survival. Conclusion The detection of neuroendocrine differentiation in conventional prostatic adenocarcinoma is not an independent indicator of prognosis.

引用

页码：287 / 290

页数：4

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