Beclin-1: Autophagic regulator and therapeutic target in cancer

被引：378

作者：

Fu, Lei-lei ^{[1
,2
]}

Cheng, Yan ^{[3
,4
]}

Liu, Bo ^{[1
,2
]}

机构：

[1] Sichuan Univ, State Key Lab Biotherapy, West China Hosp, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, Ctr Canc, Chengdu 610041, Peoples R China

[3] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Pharmacol, Hershey, PA 17033 USA

[4] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Penn State Canc Inst, Hershey, PA 17033 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2013年 / 45卷 / 05期

关键词：

Beclin-1; Autophagy; Interactome; Cancer; CASPASE-MEDIATED CLEAVAGE; INDUCED APOPTOSIS; COMPLEX; PROTEIN; PHOSPHORYLATION; PATHWAYS; RELEASE; ATG14L; DOMAIN; CELLS;

D O I：

10.1016/j.biocel.2013.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Beclin-1 (the mammalian ortholog of yeast ATG6) has been well-characterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles. Beclin-1 structure has been identified to contain three identifiable domains, including a short Bcl-2-homology-3 (BH3) motif, a central coiled-coil domain (CCD) and a C-terminal half encompassing the evolutionarily conserved domain (ECD). Recent data indicate that Beclin-1 may interact with some co-factors such as Class III phosphatidylinositol 3-kinase (PI3KCIII)/Vps34, Vps15, ATG14L/Barkor, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, Survivin, Akt and Bcl-2/Bcl-X-L to positively or negatively orchestrate the Beclin-1 interactome, thereby co-regulating the autophagy process. Here, we summarize that Beclin-1 serves not only as a key autophagic regulator with its specific interactors, but as a potential therapeutic target in cancer. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：921 / 924

页数：4

共 30 条

[1]

RAD001 (everolimus) induces autophagy in acute lymphoblastic leukemia [J].