Titanocene-catalyzed asymmetric ketone hydrosilylation: The effect of catalyst activation protocol and additives on the reaction rate and enantioselectivity

被引：173

作者：

Yun, J ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1999年 / 121卷 / 24期

关键词：

D O I：

10.1021/ja990450v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The efficient asymmetric hydrosilylation of ketones with a chiral titanocene catalyst has been realized. In this procedure, (R,R)-ethylenebis(tetrahydroindenyl) titanium difluoride (1) was used as the precatalyst, and alcohol additives were employed. Aromatic and alpha,beta-unsaturated ketones were reduced to the corresponding alcohols with a high level of enantioselectivity.

引用

页码：5640 / 5644

页数：5

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