Stability of carboplatin in 5% glucose solution exposed to light

The degradation of carboplatin (3.2 mg ml(-1) and 0.8 mg ml(-1)) in 5% glucose infusion solution at different experimental conditions was studied. It was observed that the degradation rate of carboplatin under illumination increases notably with respect to the rate obtained in the dark. The time course of carboplatin in solution follows a first-order kinetics with rate constants that depend on the incident light intensity and little with temperature. The time in which 10% of carboplatin has been degraded (t(90)) lies between 1 and 10 h depending on the experimental conditions. From the results obtained in the present work it is concluded that under clinical conditions, protection from light must be necessary.