The role of von Willebrand factor in platelet function

被引：9

作者：

de Groot, PG ^{[1
]}

机构：

[1] Univ Utrecht, Med Ctr, Haematol DL, NL-3508 GA Utrecht, Netherlands

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2002年 / 28卷 / 02期

关键词：

von Willebrand factor; platelets; platelet adhesion; glycoprotein receptors; von Willebrand disease;

D O I：

10.1055/s-2002-27815

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

von Willebrand factor (vWF) has essential functions in the very first stage of hemostasis. At the site of vascular damage vWF binds immediately to exposed collagens, thereby facilitating the adhesion of platelets. After a first layer of platelets has been formed, vWF is also crucial as a link between platelets in the forming thrombus. In this article, the current knowledge on the role of vWF in primary hemostasis is reviewed.

引用

页码：133 / 138

页数：6

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