Asymmetric synthesis of densely functionalized 3-substituted 3-hydroxy-β-lactams via novel, highly stereoselective Baylis-Hillman and allylation reactions of enantiopure 3-oxo-2-azetidinones

被引:29
作者
Alcaide, B [1 ]
Almendros, P [1 ]
Aragoncillo, C [1 ]
机构
[1] Univ Complutense, Fac Ciencias Quim, Dept Quim Organ 1, E-28040 Madrid, Spain
关键词
allylation; asymmetric synthesis; azetidinones; Baylis-Hillman reactions;
D O I
10.1016/S0040-4039(99)01527-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
New asymmetric routes based on both Baylis-Hillman and allylation reactions of enantiopure 3-oxo-2-azetidinones are used for the highly stereoselective, efficient preparation of densely functionalized 3-substituted 3-hydroxy-beta-lactams. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:7537 / 7540
页数:4
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