A Top-NOTCH Way to Make Astrocytes

被引：19

作者：

Chenn, Anjen ^{[1
]}

机构：

[1] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

DEVELOPMENTAL CELL | 2009年 / 16卷 / 02期

关键词：

STEM-CELLS; NEURONS; TUMORS; BRAIN; GLIA;

D O I：

10.1016/j.devcel.2009.01.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During mammalian nervous system development, neural precursor cells first generate neurons and then switch to astrocytes. In this issue of Developmental Cell, Namihira and colleagues show that committed neuronal precursors and young neurons promote the production of astrocytes from the remaining neural precursors by activating Notch signaling, leading to demethylation and upregulation of astrocyte-specific genes via cytokine-mediated JAK-STAT signaling.

引用

页码：158 / 159

页数：2

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