Aseptic Loosening of Total Hip Arthroplasty: Preliminary Genetic Investigation

被引：28

作者：

Godoy-Santos, Alexandre Leme ^{[1
]}

D'Elia, Caio O. ^{[1
]}

Teixeira, William J. ^{[1
]}

Cabrita, Henrique B. ^{[1
]}

Camanho, Gilberto L. ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Med, Inst Orthoped & Traumatol, Hosp Clin, Sao Paulo, Brazil

来源：

JOURNAL OF ARTHROPLASTY | 2009年 / 24卷 / 02期

关键词：

arthroplasty; hip replacement; genetics; hip prosthesis; fibroblast-type collagenase; MATRIX METALLOPROTEINASE-1 GENE; POLYMORPHISM; EXPRESSION; PROMOTER; MMP-1; RISK; PERIODONTITIS; COLLAGENASES; ASSOCIATION; PROGRESSION;

D O I：

10.1016/j.arth.2008.08.006

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Femoral and acetabular loosening call be attributed different factors, but the Causes and mechanism of early failure are still obscure, The objective of this Study was to investigate the relationship between gene polymorphisms and early implant failure. Fifty-eight patients older than 50 years was recruited for analysis of MMP-1 promoter polymorphisms in early osseointegrated implant failure. The results showed in control group a frequency of 20.97% of 2G allele and 67.74% the genotype 1G/1G whereas, in the test group, a frequency of 83.33% of 2G allele and 66.66% the genotype 2G/2G. These results indicate that the polymorphism ill the promoter of the MMP-1 gene could be it risk factor for early implant failure of total hip arthroplasty.

引用

页码：297 / 302

页数：6

共 25 条

[1]

[Anonymous], GENETICS MED

[2]

BRIKEDALHANSEN H, 1993, J PERIODONTOL, V64, P474

[3]

Brinckerhoff CE, 2000, CLIN CANCER RES, V6, P4823

[4]

CANALE ST, 2001, CAMPBELLS OPERATIVE

[5]

MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population [J].

de Souza, AP ;

Trevilatto, PC ;

Scarel-Caminaga, RM ;

Brito, RB ;

Line, SRP .

JOURNAL OF CLINICAL PERIODONTOLOGY, 2003, 30 (02) :154-158

[6]

Rapid genotype analysis of the matrix metalloproteinase-1 gene 1G/2G polymorphism that is associated with risk of cancer [J].

Dunleavey, L ;

Beyzade, S ;

Ye, S .

MATRIX BIOLOGY, 2000, 19 (02) :175-177

[7]

ENGH CA, 1988, CLIN ORTHOP RELAT R, V7, P231

[8]

A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes [J].

Fujimoto, T ;

Parry, S ;

Urbanek, M ;

Sammel, M ;

Macones, G ;

Kuivaniemi, H ;

Romero, R ;

Strauss, JF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (08) :6296-6302

[9]

Expression of matrix metalloproteinases in articular cartilage of temporomandibular and knee joints of mice during growth, maturation, and aging [J].

Gepstein, A ;

Shapiro, S ;

Arbel, G ;

Lahat, N ;

Livne, E .

ARTHRITIS AND RHEUMATISM, 2002, 46 (12) :3240-3250

[10]

A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis [J].

Golub, LM ;

Lee, HM ;

Greenwald, RA ;

Ryan, ME ;

Sorsa, T ;

Salo, T ;

Giannobile, WV .

INFLAMMATION RESEARCH, 1997, 46 (08) :310-319

← 1 2 3 →