Lessons From the Past and Promises for the Future for Carotid Intima-Media Thickness

被引：60

作者：

Bots, Michiel L. ^{[1
]}

Sutton-Tyrrell, Kim ^{[2
]}

机构：

[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3584 CX Utrecht, Netherlands

[2] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2012年 / 60卷 / 17期

基金：

美国国家卫生研究院;

关键词：

intima media thickness; risk prediction; subclinical atherosclerosis; trial; ASSOCIATION TASK-FORCE; HEART-DISEASE RISK; CARDIOVASCULAR RISK; MYOCARDIAL-INFARCTION; ATHEROSCLEROSIS RISK; ARTERY INTIMA; FAMILIAL HYPERCHOLESTEROLEMIA; SUBCLINICAL ATHEROSCLEROSIS; ULTRASOUND PROTOCOLS; META-REGRESSION;

D O I：

10.1016/j.jacc.2011.12.061

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Carotid intima-media thickness (CIMT) measurements have been used in cardiovascular research for more than 2 decades. There is a wealth of evidence showing that CIMT can be assessed in a reproducible manner and that increased CIMT relates to unfavorable risk factor levels and atherosclerosis elsewhere in the arterial system and to the risk of vascular events. Change in CIMT over time can be readily assessed, and trials showed that the rate of change is modifiable by treatment. Several issues important for the cardiovascular research community and its application in clinical practice are still outstanding. Promising future areas for CIMT measurements are: 1) application in studies among children and adolescents; 2) use of CIMT trials positioned decisively before the start of a morbidity and mortality trial; and 3) the use of CIMT measurement in risk stratification in those with an intermediate 10-year risk estimate. (J Am Coll Cardiol 2012;60:1599-604) (c) 2012 by the American College of Cardiology Foundation

引用

页码：1599 / 1604

页数：6

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