Dietary antioxidants and other dietary factors in the etiology of Parkinson's disease

被引:67
作者
Scheider, WL
Hershey, LA
Vena, JE
Holmlund, T
Marshall, JR
Freudenheim, JL
机构
[1] VET AFFAIRS MED CTR, DEPT NEUROL, BUFFALO, NY USA
[2] MILLARD FILLMORE HOSP, DENT NEUROL INST, BUFFALO, NY USA
关键词
antioxidants; carotenoids; diet; Parkinson's disease; vitamin E; vitamin C;
D O I
10.1002/mds.870120209
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
It has been suggested that dietary antioxidants reduce Parkinson's disease (PD) risk by neutralizing free radicals, thus preventing injury to neurons in the substantia nigra. This case-control study examined the possible role of long-term dietary antioxidant intake in PD etiology. Cases (n = 57) were males 45-79 years old with at least two cardinal signs of PD and no evidence of other forms of parkinsonism or dementia. Age-matched friend controls (n = 50) were chosen from lists provided by the cases. Usual dietary intake 20 years ago, including vitamins E and C and carotenoids, was assessed by a 102-item food frequency questionnaire. Odds ratios and 95% confidence intervals were calculated using conditional logistic regression. Antioxidant intake, adjusted for age, education, smoking, rural living, and total energy intake, was not associated with reduced PD risk. Trends toward greater PD risk were associated with higher intakes of vitamin C and carotenoids, especially xanthophylls, reflecting higher intakes by PD cases of fruit and certain vegetables, Intakes of sweet foods, including fruit, were associated with higher PD risk, suggesting that the observed trends may be due to a preference for sweet foods. This study does not provide support for a protective effect of long-term dietary antioxidant intake on PD risk.
引用
收藏
页码:190 / 196
页数:7
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