Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: a prospective community study

被引：107

作者：

AlYaman, F

Genton, B

Reeder, JC

Anders, RF

Smith, T

Alpers, MP

机构：

[1] PAPUA NEW GUINEA INST MED RES,MADANG,PAPUA N GUINEA

[2] PO ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,MELBOURNE,VIC 3050,AUSTRALIA

[3] SWISS TROP INST,CH-4002 BASEL,SWITZERLAND

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1997年 / 91卷 / 05期

基金：

英国医学研究理事会;

关键词：

malaria; Plasmodium falciparum; genotypes; merozoite surface proteins; protection; superinfection; Papua New Guinea;

D O I：

10.1016/S0035-9203(97)90046-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A prospective community study in a highly malaria endemic area of Papua New Guinea found that infection with multiple Plasmodium falciparum genotypes was an indicator of lowered risk of subsequent clinical attack. The results suggest that concurrent or very recent infections provide protection from superinfecting parasites. The finding of an association between reduced risk of clinical malaria and infection with parasites of merozoite surface protein 1 (MSP-1) type R033 or MSP-2 type 3D7 further suggests that the concomitant immunity is, at least in part, a consequence of a response to these major merozoite surface proteins.

引用

收藏

页码：602 / 605

页数：4

相关论文

共 20 条

[1] ASSESSMENT OF THE ROLE OF THE HUMORAL RESPONSE TO PLASMODIUM-FALCIPARUM MSP2 COMPARED TO RESA AND SPF66 IN PROTECTING PAPUA-NEW-GUINEAN CHILDREN FROM CLINICAL MALARIA [J].

ALYAMAN, F ;

GENTON, B ;

ANDERS, R ;

TARAIKA, J ;

GINNY, M ;

MELLOR, S ;

ALPERS, MP .

PARASITE IMMUNOLOGY, 1995, 17 (09) :493-501

[2] Humoral response to defined Plasmodium falciparum antigens in cerebral and uncomplicated malaria and their relationship to parasite genotype [J].

AlYaman, F ;

Genton, B ;

Reeder, JC ;

Mokela, D ;

Anders, RF ;

Alpers, MP .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1997, 56 (04) :430-435

[3] Analysis of multiple Plasmodium falciparum infections in Tanzanian children during the phase III trial of the malaria vaccine SPf66 [J].

Beck, HP ;

Felger, I ;

Huber, W ;

Steiger, S ;

Smith, T ;

Weiss, N ;

Alonso, P ;

Tanner, M .

JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (04) :921-926

[4]

BRADFORDHILL A, 1965, P ROY SOC MED, V58, P295

[5] Different genetic characteristics of Plasmodium falciparum isolates collected during successive clinical malaria episodes in Senegalese children [J].

Contamin, H ;

Fandeur, T ;

Rogier, C ;

Bonnefoy, S ;

Konate, L ;

Trape, JF ;

MercereauPuijalon, O .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1996, 54 (06) :632-643

[6] Rapid turnover of Plasmodium falciparum populations in asymptomatic individuals living in a high transmission area [J].

Daubersies, P ;

SallenaveSales, S ;

Magne, S ;

Trape, JF ;

Contamin, H ;

Fandeur, T ;

Rogier, C ;

MercereauPuijalon, O ;

Druilhe, P .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1996, 54 (01) :18-26

[7]

ENGELBRECHT F, 1995, EXPT PARASITOLOGY, V54, P18

[8] RAPID AND SIMPLE METHOD FOR ISOLATING MALARIA DNA FROM FINGERPRICK SAMPLES OF BLOOD [J].

FOLEY, M ;

RANFORDCARTWRIGHT, LC ;

BABIKER, HA .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1992, 53 (1-2) :241-244

[9] THE EPIDEMIOLOGY OF MALARIA IN THE WOSERA AREA, EAST SEPIK PROVINCE, PAPUA-NEW-GUINEA, IN PREPARATION FOR VACCINE TRIALS .2. MORTALITY AND MORBIDITY [J].

GENTON, B ;

ALYAMAN, F ;

BECK, HP ;

HII, J ;

MELLOR, S ;

RARE, L ;

GINNY, M ;

SMITH, T ;

ALPERS, MP .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1995, 89 (04) :377-390

[10] THE EPIDEMIOLOGY OF MALARIA IN THE WOSERA AREA, EAST SEPIK PROVINCE, PAPUA-NEW-GUINEA, IN PREPARATION FOR VACCINE TRIALS .1. MALARIOMETRIC INDEXES AND IMMUNITY [J].

GENTON, B ;

ALYAMAN, F ;

BECK, HP ;

HII, J ;

MELLOR, S ;

NARARA, A ;

GIBSON, N ;

SMITH, T ;

ALPERS, MP .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1995, 89 (04) :359-376