Perspectives on transdermal scopolamine for the treatment of postoperative nausea and vomiting

被引：51

作者：

Pergolizzi, Joseph V., Jr. ^{[1
,2
,3
]}

Philip, Beverly K. ^{[4
,5
]}

Leslie, John B. ^{[6
,7
]}

Taylor, Robert, Jr. ^{[8
]}

Raffa, Robert B. ^{[9
]}

机构：

[1] Johns Hopkins Univ, Dept Med, Baltimore, MD 21287 USA

[2] Georgetown Univ, Sch Med, Dept Anesthesiol, Washington, DC 20057 USA

[3] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19122 USA

[4] Harvard Univ, Sch Med, Dept Anaesthesia, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA

[6] Mayo Clin Arizona, Dept Anesthesiol, Scottsdale, AZ 85259 USA

[7] Mayo Clin & Mayo Fdn, Mayo Med Sch, Dept Anesthesiol, Rochester, MN 55905 USA

[8] NEMA Res, Naples, FL 34108 USA

[9] Temple Univ, Sch Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19140 USA

来源：

JOURNAL OF CLINICAL ANESTHESIA | 2012年 / 24卷 / 04期

关键词：

Antiemetics; Postdischarge nausea and vomiting; Postoperative nausea and vomiting; Transdermal scopolamine; MIDDLE-EAR SURGERY; DOUBLE-BLIND; DOSE-RESPONSE; CLINICAL-USE; RISK SCORE; PREVENTION; HYOSCINE; ONDANSETRON; EFFICACY; PHARMACOKINETICS;

D O I：

10.1016/j.jclinane.2011.07.019

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

Transdermal scopolamine, a patch system that delivers 1.5 mg of scopolamine gradually over 72 hours following an initial bolus, was approved in the United States in 2001 for the prevention of postoperative nausea and vomiting (PONV) in adults. Scopolamine (hyoscine) is a selective competitive anatagonist of muscarinic cholinergic receptors. Low serum concentrations of scopolamine produce an antiemetic effect. Transdermal scopolamine is effective in preventing PONV versus placebo [relative risk (RR)=0.77, 95% confidence interval (CI), 0.61-0.98, P = 0.03] and a significantly reduced risk for postoperative nausea (RR=0.59, 95% CI, 0.48-0.73, P < 0.001), postoperative vomiting (RR=0.68, 95% CI, 0.61-0.76, P < 0.001), and PONV (RR 0.73, 95% CI, 0.60-0.88, P = 001) in the first 24 hours after the start of anesthesia. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：334 / 345

页数：12

共 60 条

[1]

[Anonymous], 2009, INPATIENT SURG

[2]

[Anonymous], 2006, TRANSDERMAL SCOPOLAM

[3]

A simplified risk score for predicting postoperative nausea and vomiting -: Conclusions from cross-validations between two centers [J].